2020 - present (Principal Investigator at Zhejiang University)

2024

• The role of lipoylation in mitochondrial adaptation to methionine restriction. Xue J and Ye C (2024) Bioassays. e2300218.
• Low-input lipidomics reveals lipid metabolism remodeling during early mammalian embryo development. Zhang L, Zhao J, Lam SM, Chen L, Gao Y, Wang W, Xu Y, Tan T, Yu H, Zhang M, Liao X, Wu M, Zhang T, Huang J, Li B, Zhou QD, Shen N, Lee HJ, Ye C, Li D, Shui G, Zhang J (2024) Nat Cell Biol. 26(2):278-293.
• Innate immunity sensing of lysosomal dysfunction drives multiple lysosomal storage disorders. Wang A, Chen C, Mei C, Liu S, Xiang C, Fang W, Zhang F, Xu Y, Chen S, Zhang Q, Bai X, Lin A, Neculai D, Xia B, Ye C, Zou J, Liang T, Feng XH, Li X, Shen C, Xu P (2024) Nat Cell Biol. 26(2):219-234.
• Ethanolamine as a biomarker and biomarker-based therapy for diabetic retinopathy in glucose-well-controlled diabetic patients. Hu G, Gu L, Wang R, Jian Q, Lv K, Xia M, Lai M, Shen T, Hu J, Yang S, Ye C, Zhang X, Wang Y, Xu X, Zhang F (2024)  Sci Bull. doi:10.1016/j.scib.2023.12.053.
• MAPK1 mediates MAM disruption and mitochondrial dysfunction in diabetic kidney disease via the PACS-2-dependent mechanism. Liu S, Han S, Wang C, Chen H, Xu Q, Feng S, Wang Y, Yao J, Zhou Q, Tang X, Lin L, Hu L, Davidson AJ, Yang B, Ye C, Yang F, Mao J, Tong C, Chen J, Jiang H (2024) Int J Bio Sci. 20(2):569-584.

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2023

• Methionine restriction constrains lipoylation and activates mitochondria for nitrogenic synthesis of amino acids. Fang W*, Jiang L*, Zhu Y*, Yang S, Qiu H, Cheng J, Liang Q, Tu Z, Ye C (2023) Nature Commun. 14:2504.
• Spatial sterol metabolism unveiled by stimulated Raman imaging.  Zhang Y*, Zhou Y*, Fang W*, Zhu H, Cao W, Ye C#, Zhang D#, Lee HJ# (2023) Front. Chem. 11:1166313.

2022

• Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha. Zhou Q, Hao B, Cao X, Gao L, Yu Z, Zhao Y, Zhu M, Zhong G, Chi F, Dai X, Mao J, Zhu Y, Rong P, Chen L, Bai X, Ye C, Chen S, Liang T, Li L, Feng XH, Tan M, Zhao B (2022) Mol. Cell 82(24):4700-4711.
• Protocol for rapid and accurate quantification of phospholipids using LC-MS. Yang S, Xue J, Ye C (2022) STAR Protocols 3(4):101769.
• Serum Metabolomics Benefits Discrimination Kidney Disease Development in Type 2 Diabetes Patients.  Peng X, Wang X, Shao X, Wang Y, Feng S, Wang C, Ye C, Chen J, Jiang H (2022) Front Med (Lausanne). 9:819311.
• FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated mitochondrial fusion. Li S*, Han S*, Zhang Q, Zhu Y, Zhang H, Wang J, Zhao Y, Zhao J, Su L, Li L, Zhou D, Ye C, Feng XH, Liang T, Zhao B (2022) Nature Commun. 13(1):3486.
• Reciprocal regulation of phosphatidylcholine synthesis and H3K36 methylation programs metabolic adaptation. Fang W*, Zhu Y*, Yang S, Tong X, Ye C (2022) Cell Reports 39(2) 110672.
• Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth. Zhao JS#, Shi S, Qu HY, Keckesova Z, Cao ZJ, Yang LX, Yu X, Feng L, Shi Z, Krakowiak J, Mao RY, Shen YT, Fan YM, Fu TM, Ye C, Xu D, Gao X, You J, Li W, Liang T#, Lu Z#, Feng YX# (2022)  Nat. Metab. 4(2):239-253.

2021

• Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn's disease.  Huang LJ, Mao XT, Li YY, Liu DD, Fan KQ, Liu RB, Wu TT, Wang HL, Zhang Y, Yang B, Ye C, Zhong JY, Chai RJ, Cao Q, Jin J (2021)  Immunity 54(8):1728-1744.
• Inhibition of Syk promotes chemical reprogramming of fibroblasts via metabolic rewiring and H2 S production. Wang W, Ren S, Lu Y, Chen X, Qu J, Ma X, Deng Q, Hu Z, Jin Y, Zhou Z, Ge W, Zhu Y, Yang N, Li Q, Pu J, Chen G, Ye C, Wang H, Zhao X, Liu Z, Zhu S (2021). EMBO J. 40 (11) e106771.

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2020

•  Cardiolipin-deficient cells have decreased levels of the iron-sulfur biogenesis protein frataxin.   Li Y, Lou W, Grevel A, Böttinger L, Liang Z, Ji J, Patil VA, Liu J, Ye C, Hüttemann M, Becker T, Greenberg ML (2020) J. Biol. Chem. 295(33):11928-11937.
• Methyl-metabolite depletion elicits adaptive responses to support heterochromatin stability and epigenetic persistence.  Haws SA, Yu D, Ye C, Wille CK, Nguyen LC, Krautkramer KA, Tomasiewicz JL, Yang SE, Miller BR, LiuWH, Igarashi K, Sridharan R, Tu BP, Cryns VL, Lamming DW, Denu JM (2020) Mol. Cell 78(2):210-223.

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​2015 - 2019 Postdoctoral Research at UT Southwestern Medical Center)​​

• ​The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3.
  Kuang Z, Wang Y, Li Y, Ye C, Ruhn KA, Behrendt CL, Olson EN, Hooper LV (2019) Science. 365(6460):1428-1434. 
• Demethylation of the protein phosphatase PP2A promotes demethylation of histones to enable their function as a methyl group sink.  Ye C , Sutter BM, Wang Y, Kuang Z, Zhao X, Yu Y, Tu BP (2019) Mol. Cell. 73(6):1115-1126.
• Sink into the Epigenome: Histones as repositories that influence cellular metabolism. Ye C and Tu BP (2018). Trends in Endocrinology & Metabolism. 29(9): 626-637.
• A metabolic function for phospholipid and histone methylation. Ye C, Sutter BM, Wang Y, Kuang Z, Tu BP (2017)  Mol. Cell. 66(2):180-193.​

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2008 - 2014 Graduate Research at Wayne State University

• Inositol hexakisphosphate kinase 1 (IP6K1) regulates inositol synthesis in mammalian cells. Yu W*, Ye C*, and Greenberg ML (2016).  J. Biol. Chem. 291(20): 10437-10444.
•  Cardiolipin remodeling: a regulatory hub for modulating cardiolipin metabolism and function. Ye C, Shen Z, and Greenberg ML (2015). J. Bioenerg. Biomembr. 48(2): 113-123.
• The role of cardiolipin in cardiovascular health.  Shen Z, Ye C, McCain K, and Greenberg ML (2015). BioMed Res. Int. 2015:891707. ​
• Inositol synthesis regulates activation of GSK-3α in neuronal cells. Ye C and Greenberg ML (2015).  J. Neurochem. 133(2):273-83.
• Deletion of the cardiolipin-specific phospholipase Cld1 rescues growth and lifespan defects in the tafazzin mutant: Implications for Barth syndrome. Ye C*, Lou W*, Li Y, Chatzispyrou IA, Hüttemann M, Lee I, Houtkooper RH, Vaz FM, Chen S, Greenberg ML (2014) J. Biol. Chem. 289(6):3114-25.
• Regulation of inositol metabolism is fine-tuned by inositol pyrophosphates in Saccharomyces cerevisiae. Ye C, Bandara WMMS, Greenberg ML (2013).  J. Biol. Chem. 288(34):24898-908.

          * Co-first authors, # Co-corresponding authors